Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID-19. Academic Article uri icon

Overview

abstract

  • Cognitive post-acute sequelae of SARS-CoV-2 (PASC) can occur after mild COVID-19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS-CoV-2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%). Delayed onset of cognitive PASC occurred in 43% and associated with younger age. Cognitive PASC participants had a higher number of pre-existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls. Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis.

publication date

  • January 19, 2022

Research

keywords

  • COVID-19
  • Cerebrospinal Fluid
  • Cognition
  • SARS-CoV-2

Identity

Digital Object Identifier (DOI)

  • 10.1002/acn3.51498

PubMed ID

  • 35043593