Dysregulation and therapeutic targeting of RNA splicing in cancer. Review uri icon

Overview

abstract

  • High-throughput sequencing and functional characterization of the cancer transcriptome have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers. Alterations in the cancer genome and dysregulation of RNA splicing factors lead to missplicing, splicing alteration-dependent gene expression and, in some cases, generation of novel splicing-derived proteins. Here, we review recent advances in our understanding of aberrant splicing in cancer pathogenesis and present strategies to harness cancer-specific aberrant splicing for therapeutic intent.

publication date

  • May 27, 2022

Research

keywords

  • Neoplasms
  • RNA Splicing

Identity

PubMed Central ID

  • PMC9551392

Scopus Document Identifier

  • 85130855221

Digital Object Identifier (DOI)

  • 10.1038/s43018-022-00384-z

PubMed ID

  • 35624337

Additional Document Info

volume

  • 3

issue

  • 5