The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. Academic Article uri icon

Overview

abstract

  • Since the publication of the Revised European-American Classification of Lymphoid Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have been generated through iterative international efforts to achieve broad consensus among hematopathologists, geneticists, molecular scientists, and clinicians. Significant progress has recently been made in the characterization of malignancies of the immune system, with many new insights provided by genomic studies. They have led to this proposal. We have followed the same process that was successfully used for the third and fourth editions of the World Health Organization Classification of Hematologic Neoplasms. The definition, recommended studies, and criteria for the diagnosis of many entities have been extensively refined. Some categories considered provisional have now been upgraded to definite entities. Terminology for some diseases has been revised to adapt nomenclature to the current knowledge of their biology, but these modifications have been restricted to well-justified situations. Major findings from recent genomic studies have impacted the conceptual framework and diagnostic criteria for many disease entities. These changes will have an impact on optimal clinical management. The conclusions of this work are summarized in this report as the proposed International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors.

authors

publication date

  • September 15, 2022

Research

keywords

  • Hematologic Neoplasms
  • Lymphoma

Identity

PubMed Central ID

  • PMC9479027

Scopus Document Identifier

  • 85132911627

Digital Object Identifier (DOI)

  • 10.1182/blood.2022015851

PubMed ID

  • 35653592

Additional Document Info

volume

  • 140

issue

  • 11