Experimental drusen formation induced by intravitreal aminoglycoside injection. Academic Article uri icon

Overview

abstract

  • A single intravitreal injection of aminoglycoside antibiotics in the rabbit induces changes in the retinal pigment epithelial layer that consist of disseminated yellow-white dots that are apparent six to ten months after injection. With fluorescein angiography, these dots have the characteristics of window defects or drusen. Histologic examination disclosed subepithelial amorphous material that stained positively with both periodic acid-Schiff and oil red O. Ultrastructural examination disclosed lipidic inclusions in the retinal pigment epithelial cells, basally directed cellular evagination, and basal accumulation of granular material, findings consistent with the reported morphologic features of hard drusen. These findings suggest that aminoglycoside-induced lesions may represent a model for retinal pigment epithelial degeneration and drusen formation.

publication date

  • June 1, 1987

Research

keywords

  • Aminoglycosides
  • Lipidoses
  • Vitreous Body

Identity

Scopus Document Identifier

  • 0023216011

Digital Object Identifier (DOI)

  • 10.1001/archopht.1987.01060060112044

PubMed ID

  • 3579714

Additional Document Info

volume

  • 105

issue

  • 6