Standard clinical approaches and emerging modalities for glioblastoma imaging. Review uri icon

Overview

abstract

  • Glioblastoma (GBM) is the most common primary adult intracranial malignancy and carries a dismal prognosis despite an aggressive multimodal treatment regimen that consists of surgical resection, radiation, and adjuvant chemotherapy. Radiographic evaluation, largely informed by magnetic resonance imaging (MRI), is a critical component of initial diagnosis, surgical planning, and post-treatment monitoring. However, conventional MRI does not provide information regarding tumor microvasculature, necrosis, or neoangiogenesis. In addition, traditional MRI imaging can be further confounded by treatment-related effects such as pseudoprogression, radiation necrosis, and/or pseudoresponse(s) that preclude clinicians from making fully informed decisions when structuring a therapeutic approach. A myriad of novel imaging modalities have been developed to address these deficits. Herein, we provide a clinically oriented review of standard techniques for imaging GBM and highlight emerging technologies utilized in disease characterization and therapeutic development.

publication date

  • May 26, 2022

Identity

PubMed Central ID

  • PMC9268747

Scopus Document Identifier

  • 85134994325

Digital Object Identifier (DOI)

  • 10.1093/noajnl/vdac080

PubMed ID

  • 35821676

Additional Document Info

volume

  • 4

issue

  • 1