Caregiver willingness to give TPT to children living with drug-resistant TB patients. Academic Article uri icon

Overview

abstract

  • BACKGROUND Pediatric household contacts (HHCs) of patients with multidrug-resistant TB (MDR-TB) are at high risk of infection and active disease. Evidence of caregiver willingness to give MDR-TB preventive therapy (TPT) to children is limited.METHODS This was a cross-sectional study of HHCs of patients with MDR-TB to assess caregiver willingness to give TPT to children aged <13 years.RESULTS Of 743 adult and adolescent HHCs, 299 reported caring for children aged <13 years of age. The median caregiver age was 35 years (IQR 27-48); 75% were women. Among caregivers, 89% were willing to give children MDR TPT. In unadjusted analyses, increased willingness was associated with TB-related knowledge (OR 5.1, 95% CI 2.3-11.3), belief that one can die of MDR-TB (OR 5.2, 95% CI 1.2-23.4), concern for MDR-TB transmission to child (OR 4.5, 95% CI 1.6-12.4), confidence in properly taking TPT (OR 4.5, 95% CI 1.6-12.6), comfort telling family about TPT (OR 5.5, 95% CI 2.1-14.3), and willingness to take TPT oneself (OR 35.1, 95% CI 11.0-112.8).CONCLUSIONS A high percentage of caregivers living with MDR- or rifampicin-resistant TB patients were willing to give children a hypothetical MDR TPT. These results provide important evidence for the potential uptake of effective MDR TPT when implemented.

authors

  • Rouzier, Vanessa
  • Murrill, M
  • Kim, S
  • Naini, L
  • Shenje, J
  • Mitchell, E
  • Raesi, M
  • Lourens, M
  • Mendoza, A
  • Conradie, F
  • Suryavanshi, N
  • Hughes, M
  • Shah, S
  • Churchyard, G
  • Swindells, S
  • Hesseling, A
  • Gupta, A

publication date

  • October 1, 2022

Research

keywords

  • Caregivers
  • Tuberculosis, Multidrug-Resistant

Identity

Digital Object Identifier (DOI)

  • 10.5588/ijtld.21.0760

PubMed ID

  • 36163664

Additional Document Info

volume

  • 26

issue

  • 10