Cholesterol: Enhancing FGF2 translocation in unconventional secretion. uri icon

Overview

abstract

  • Fibroblast growth factor (FGF2) is a potent mitogen that is secreted through an unconventional secretory pathway by crossing the plasma membrane directly. In this current issue, Lolicato et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202106123) find that the secretion process is promoted by cholesterol, which enhances PI(4,5)P2 accessibility to FGF2 binding and alters membrane property to increase FGF2 translocation.

publication date

  • October 18, 2022

Research

keywords

  • Cholesterol
  • Fibroblast Growth Factor 2

Identity

PubMed Central ID

  • PMC9582227

Scopus Document Identifier

  • 85141383438

Digital Object Identifier (DOI)

  • 10.1083/jcb.202210007

PubMed ID

  • 36255389

Additional Document Info

volume

  • 221

issue

  • 11