The Role of Nuclear Actin in Genome Organization and Gene Expression Regulation During Differentiation. Review uri icon

Overview

abstract

  • In the cell nucleus, actin participates in numerous essential processes. Actin is involved in chromatin as part of specific ATP-dependent chromatin remodeling complexes and associates with the RNA polymerase machinery to regulate transcription at multiple levels. Emerging evidence has also shown that the nuclear actin pool controls the architecture of the mammalian genome playing an important role in its hierarchical organization into transcriptionally active and repressed compartments, contributing to the clustering of RNA polymerase II into transcriptional hubs. Here, we review the most recent literature and discuss how actin involvement in genome organization impacts the regulation of gene programs that are activated or repressed during differentiation and development. As in the cytoplasm, we propose that nuclear actin is involved in key nuclear tasks in complex with different types of actin-binding proteins that regulate actin function and bridge interactions between actin and various nuclear components.

publication date

  • January 1, 2022

Research

keywords

  • Actins
  • Cell Nucleus

Identity

PubMed Central ID

  • 3021903

Scopus Document Identifier

  • 85141893780

Digital Object Identifier (DOI)

  • 10.1007/978-3-031-06573-6_22

PubMed ID

  • 36348124

Additional Document Info

volume

  • 70