Construction of a Secondary Enclosure for UVB Irradiation of Mice. Academic Article uri icon

Overview

abstract

  • UV irradiation is commonly used in murine models of skin cancers. Despite the popularity of using UVB rays to model photocarcinogenesis in animals, there is a lack of standardization in the secondary enclosures used to administer radiation. An appraisal of the literature also shows a general lack of details regarding the materials and procedures utilized in the fabrication of such enclosures. We present in this study a detailed overview of the construction of a UVB exposure chamber that successfully induces lesions in hairless mice. A standardized protocol for producing a UVB enclosure may reduce methodological variation in future studies seeking to investigate photocarcinogenesis in animals.

authors

  • Choi, Justin
  • Bordeaux, Zachary A
  • Braun, Gabriella
  • Davis, Cole
  • Parthasarathy, Varsha
  • Deng, Junwen
  • Taylor, Mathew T
  • Kambala, Anusha
  • Cornman, Hannah
  • Oladipo, Olusola
  • Alphonse, Martin P
  • West, Cameron E
  • Kwatra, Shawn G
  • Kwatra, Madan M

publication date

  • September 29, 2022

Identity

PubMed Central ID

  • PMC9872852

Scopus Document Identifier

  • 85149607830

Digital Object Identifier (DOI)

  • 10.1016/j.xjidi.2022.100164

PubMed ID

  • 36704704

Additional Document Info

volume

  • 3

issue

  • 1