Store Operated Ca2+ Entry is a ubiquitous signaling module with established roles in the immune system, secretion, and muscle development. Recent evidence supports a complex role for SOCE in the nervous system. In this review we present an update of the current knowledge on SOCE function in the brain with a focus on its role as a regulator of brain activity and excitability Abstract figure legend Store Operated Ca2+ Entry is a ubiquitous signaling module with established roles in the immune system, secretion, and muscle development. Recent evidence supports a complex role for SOCE in the nervous system. In this review we present an update of the current knowledge on SOCE function in the brain with a focus on its role as a regulator of brain activity and excitability. This article is protected by copyright. All rights reserved.
