T-SPOT.TB reactivity in Southern African children with and without in utero HIV exposure. Academic Article

Overview

abstract

Infants HIV-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared TB infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

authors

Edlefsen, Paul T

Bhebhe, Lynnette

Moyo, Sikhulile

Happel, Anna-Ursula

Mmasa, Nicholas

Gasper, Melanie A

Dubois, Melanie
Files, Megan A
Seshadri, Chetan
Duffy, Fergal
Aitchison, John
Netea, Mihai G
Jao, Jennifer
Cameron, Donald W
Gray, Clive M
Jaspan, Heather B
Powis, Kathleen M

publication date

June 9, 2023

published in

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Journal

Research

keywords

HIV Infections
Latent Tuberculosis
Tuberculosis

Identity

Digital Object Identifier (DOI)

10.1093/cid/ciad356

PubMed ID

37293702