Dermatologic complications in transplantation and cellular therapy for acute leukemia. Review uri icon

Overview

abstract

  • Adoptive cellular immunotherapy, mainly hematopoietic stem cell transplant and CAR-T cell therapy have revolutionized treatment of patients with acute leukemia. Indications and inclusion criteria for these treatments have expanded in recent years. While these therapies are associated with significant improvements in disease response and overall survival, patients may experience adverse events from associated chemotherapy conditioning, engraftment, cytokine storm, supportive medications, and post-transplant maintenance targeted therapies. Supportive oncodermatology is a growing specialty to manage cutaneous toxicities resulting from the anti-cancer therapies. In this review, we summarize diagnosis and management of the common cutaneous adverse events including drug eruptions, graft-versus-host disease, neoplastic and paraneoplastic complications in patients undergoing cellular therapies.

publication date

  • April 6, 2023

Research

keywords

  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation
  • Leukemia, Myeloid, Acute

Identity

PubMed Central ID

  • PMC10291442

Scopus Document Identifier

  • 85152740848

Digital Object Identifier (DOI)

  • 10.1016/j.beha.2023.101464

PubMed ID

  • 37353285

Additional Document Info

volume

  • 36

issue

  • 2