Predicting Overall Survival in METABRIC Cohort Using Machine Learning.

Overview

Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that presents very high relapse and mortality. However, due to differences in the genetic architecture associated with TNBC, patients have different outcomes and respond differently to available treatments. In this study, we predicted the overall survival of TNBC patients in the METABRIC cohort employing supervised machine learning to identify important clinical and genetic features that are associated with better survival. We achieved a slightly higher Concordance index than the state of art and identified biological pathways related to the top genes considered important by our model.