Fluid resuscitation in acute pancreatitis. Review uri icon

Overview

abstract

  • PURPOSE OF REVIEW: The purpose of the review is to critically evaluate the evidence from the literature to establish the current perspective on fluid resuscitation (FR) in acute pancreatitis (AP). We will review the rationale, type of fluid, rate of administration, total volume, duration, monitoring, ideal outcomes to be studied in clinical trials and recommendations for future studies. RECENT FINDINGS: FR remains the key component of supportive therapy in AP. The paradigm has shifted from administration of aggressive fluid resuscitation towards more moderate FR strategies. Lactated Ringer's remains the preferred fluid for resuscitation. There remain critical gaps in knowledge regarding the end point(s) to indicate adequate resuscitation, and accurate assessments of fluid sequestration and intravascular volume deficit in AP. SUMMARY: There is insufficient evidence to state that goal-directed therapy, using any of the parameters to guide fluid administration, reduces the risk of persistent organ failure, infected pancreatic necrosis, or mortality in AP, as well as the most appropriate method for the same.

publication date

  • July 5, 2023

Research

keywords

  • Pancreatitis, Acute Necrotizing

Identity

Scopus Document Identifier

  • 85166396251

Digital Object Identifier (DOI)

  • 10.1097/MOG.0000000000000959

PubMed ID

  • 37421393

Additional Document Info

volume

  • 39

issue

  • 5