The effect of macromolecular conjugates of daunorubicin on nuclear ultrastructure in Trypanosoma brucei rhodesiense. Academic Article uri icon

Overview

abstract

  • The effects of free and conjugated daunorubicin on T.b. rhodesiense in vitro are described. Free drug caused nucleolar lesions ranging from segregation to complete fragmentation. At equimolar concentrations a soluble bovine serum albumin conjugate with a stable succinyl linkage (D-BSAS) produced no ultrastructural lesions whereas a conjugate with a labile glutaraldehyde linkage (D-BSAG) and a conjugate linked to large agarose beads (D-ag) produced similar though less severe lesions than free drug. Polyisobutylcyanoacrylate nanoparticles caused trypanosomal lysis both with (D-PICA) and without adsorbed daunorubicin.

publication date

  • September 1, 1986

Research

keywords

  • Cell Nucleus
  • Cyanoacrylates
  • Daunorubicin
  • Serum Albumin, Bovine
  • Trypanosoma brucei brucei

Identity

Scopus Document Identifier

  • 0022979060

PubMed ID

  • 3757066

Additional Document Info

volume

  • 10

issue

  • 9