CD40 agonism improves anti-tumor T cell priming induced by the combination of radiation therapy plus CTLA4 inhibition and enhances tumor response. Academic Article uri icon

Overview

abstract

  • Radiation therapy (RT) combined with CTLA4 blockers converts immunosuppressed (cold) mouse triple negative breast cancers (TNBCs) into immune infiltrated (hot) lesions. We have recently shown that targeting the myeloid compartment to improve dendritic cell activation is required for most TNBC-bearing mice to achieve superior therapeutic responses to RT plus CTLA4 inhibitors.

publication date

  • September 15, 2023

Research

keywords

  • Immune Checkpoint Inhibitors
  • Triple Negative Breast Neoplasms

Identity

PubMed Central ID

  • PMC10506429

Digital Object Identifier (DOI)

  • 10.1080/2162402X.2023.2258011

PubMed ID

  • 37727740

Additional Document Info

volume

  • 12

issue

  • 1