BNIP3 as a new tool to promote healthy brain aging. Review uri icon

Overview

abstract

  • The article "Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in Drosophila" reveals BCL2-interacting protein 3 as a therapeutic target to counteract brain aging and prolong overall organismal health with age. In this spotlight, we consider the roles of BNIP3, a mitochondrial outer membrane protein, in the adult nervous system, including its induction of mitophagy and prevention of dysfunctional mitochondria in the aged brain. Implications for other tissue types to reduce the burden of aging are further considered.

publication date

  • November 29, 2023

Research

keywords

  • Mitochondria
  • Mitochondrial Proteins

Identity

PubMed Central ID

  • PMC10861191

Scopus Document Identifier

  • 85178248615

Digital Object Identifier (DOI)

  • 10.1111/acel.14042

PubMed ID

  • 38030595

Additional Document Info

volume

  • 23

issue

  • 2