[Alternative complement pathway (author's transl)]. Review uri icon

Overview

abstract

  • The dual role of the alternative complement pathway in recognition of foreign substances by a non-immune host and in the intrinsic regulation of the complement sequence is now well recognized. Activation of this pathway occurs through escape from its regulatory mechanisms induced by the activating principle; its functional expression depends on the respective levels of the component proteins C3, factor B, factor D and properdin, and on the control proteins beta 1H and C3bINA. This article presents recently acquired knowlege on the molecular mechanisms of activation, regulation and behaviour under pathological conditions of the alternative complement pathway.

publication date

  • June 9, 1979

Research

keywords

  • Complement Activation
  • Complement Pathway, Alternative

Identity

Scopus Document Identifier

  • 0018359143

PubMed ID

  • 382108

Additional Document Info

volume

  • 8

issue

  • 26