Changes in wider field swept-source OCT angiography vascular metrics with anti-vascular endothelial growth factor therapy in central retinal vein occlusion. Academic Article uri icon

Overview

abstract

  • PURPOSE: To investigate the impact of anti-VEGF therapy on vascular metrics in eyes with macular edema secondary to central retinal vein occlusion (CRVO) using wider field swept-source OCT angiography (WF SS-OCTA). METHODS: We included 23 eyes with macular edema associated with non-ischemic CRVO from 22 patients treated with anti-VEGF therapy (median number of injections: 5 [2-9]). Changes in vessel density (VD), vessel skeletonized density (VSD), and foveal avascular zone (FAZ) parameters were measured using WF SS-OCTA. Visual acuity (VA) and central subfield thickness (CST) were also measured. RESULTS: Median CST decreased significantly from 369 µm (305-531) to 267 µm (243-300, p < 0.001). VD and VSD parameters in 12 × 12 mm images showed significant reductions. For instance, VSD in the whole retina decreased from a median of 13.37 (11.22-13.74) to 11.29 (9.36-12.97, p = 0.013). Additionally, a significant increase in FAZ circularity was found, suggesting improved microvascular integrity. Significant inverse correlations were found between the number of anti-VEGF injections and all VSD and VD parameters on the 12 × 12 mm images (p < 0.05). Notably, the reductions in VSD and VD on 12 × 12 mm angiograms in the deep capillary plexus (DCP) after each injection significantly correlated with increased logMAR VA (worse VA). CONCLUSION: Anti-VEGF therapy in CRVO patients not only mitigates macular edema but also alters the overall microvascular morphology and functionality as revealed by WF SS-OCTA.

authors

  • Razavi, Peyman
  • Baldwin, Grace
  • Garg, Itika
  • Velazquez, Luis Martinez
  • Garcia, Mauricio
  • Gan, Jenny
  • Choi, Hanna
  • Zeng, Rebecca
  • Vingopoulos, Filippos
  • Husain, Deeba
  • Kim, Leo A
  • Patel, Nimesh A
  • Miller, John B

publication date

  • February 20, 2024

Research

keywords

  • Angiogenesis Inhibitors
  • Ranibizumab
  • Retinal Vein Occlusion
  • Tomography, Optical Coherence

Identity

Scopus Document Identifier

  • 85185940334

Digital Object Identifier (DOI)

  • 10.1007/s00417-024-06410-3

PubMed ID

  • 38376563

Additional Document Info

volume

  • 262

issue

  • 7