SWI/SNF regulation of germinal center fate and lymphomagenesis. Academic Article uri icon

Overview

abstract

  • The mSWI/SNF subunits ARID1A and SMARCA4 are mutated in B cell lymphomas. Now, Barisic et al. and Deng et al. find that loss of ARID1A or SMARCA4 contributes to lymphomagenesis by causing B cells to aberrantly re-enter germinal centers where they undergo repeated rounds of proliferation and somatic hypermutation.

publication date

  • March 7, 2024

Research

keywords

  • DNA Helicases
  • Germinal Center

Identity

PubMed Central ID

  • PMC11318343

Scopus Document Identifier

  • 85189513013

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2024.02.006

PubMed ID

  • 38458185

Additional Document Info

volume

  • 42

issue

  • 4