Widefield, Swept-Source Optical Coherence Tomography Angiography Metrics as Predictors of Anti-VEGF Treatment in Retinal Vein Occlusions. Academic Article uri icon

Overview

abstract

  • BACKGROUND AND OBJECTIVE: Our objective was to assess baseline widefield swept-source optical coherence tomography angiography (WF SSOCTA) microvascular metrics as predictors for the number of anti-vascular endothelial growth factor (VEGF) injections and visual acuity (VA) at 12-months follow-up in patients with retinal vein occlusion (RVO). PATIENTS AND METHODS: This was a prospective study including 49 RVO eyes from 49 patients who had not received an anti-VEGF injection for at least 3 months prior to imaging. Microvascular metrics from 6×6-mm and 12×12-mm angiograms were assessed using linear regression models, adjusting for age. RESULTS: Reductions in the vessel density (VD) and vessel skeletonized density (VSD) vascular metrics were associated both with a higher number of anti-VEGF injections at all follow-up time points and reduced VA 12 months after imaging in all RVO eyes. CONCLUSIONS: WF SS-OCTA VD and VSD micro-vascular metrics at baseline can prognosticate VA and number of anti-VEGF injections required at 3, 6, and 12 months in RVO eyes. [Ophthalmic Surg Lasers Imaging Retina 2024;55:374-382.].

publication date

  • March 1, 2024

Research

keywords

  • Angiogenesis Inhibitors
  • Fluorescein Angiography
  • Intravitreal Injections
  • Retinal Vein Occlusion
  • Tomography, Optical Coherence
  • Vascular Endothelial Growth Factor A
  • Visual Acuity

Identity

Scopus Document Identifier

  • 85199125490

Digital Object Identifier (DOI)

  • 10.3928/23258160-20240208-02

PubMed ID

  • 38531003

Additional Document Info

volume

  • 55

issue

  • 7