Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor. Academic Article uri icon

Overview

abstract

  • •Circuit thrombosis complicates CRRT in COVID-19 despite standard heparin-based anticoagulation regimens.•5 cases of CRRT thrombosis despite heparin-based anticoagulation resolved using a direct thrombin inhibitor, argatroban.•Changes in fibrinogen levels better reflected response to anticoagulation than did changes in D-dimer levels.•High fibrinogen levels and decreased anti-thrombin III activity may relate to argatroban superiority in these cases.

publication date

  • September 8, 2020

Identity

PubMed Central ID

  • PMC7476895

Scopus Document Identifier

  • 85094661778

Digital Object Identifier (DOI)

  • 10.1016/j.tru.2020.100009

PubMed ID

  • 38620488

Additional Document Info

volume

  • 1