Seeing is believing: a breakthrough to visualize necrosomes in the tissue.
Article
Overview
abstract
Detection of necroptosis in the tissue has been a long-standing roadblock in determining the disease states and pathological conditions associated with this inflammatory form of cell death. In this issue of EMBO Molecular Medicine, Chiou et al report a definitive method for necroptosis detection in situ (Chiou et al, 2024). The authors utilize this technical advance to unequivocally identify necroptosis lesions within the intestinal epithelium, and further reveal the simultaneous presence of distinct apoptotic and necroptotic lesions in human inflammatory bowel disease.
