Total synthesis of dissectol A, using an enediolate-based Tsuji-Trost reaction. Academic Article uri icon

Overview

abstract

  • Dissectol A is a rearranged terpene glycoside isolated from several flowering plants. Starting from glucose, the densely functionalized bicyclic structure has been prepared via site-selective oxidation and an intramolecular allylic alkylation reaction with an enediolate as the nucleophile. Despite earlier reports, dissectol A is not effective at inhibiting DevRS signaling in whole-cell Mycobacterium tuberculosis and does not inhibit growth of the bacterium.

publication date

  • June 7, 2024

Identity

PubMed Central ID

  • PMC11234881

Scopus Document Identifier

  • 85195827391

Digital Object Identifier (DOI)

  • 10.1039/d4sc01745e

PubMed ID

  • 38994423

Additional Document Info

volume

  • 15

issue

  • 27