Chromosomal instability as a driver of cancer progression. Review uri icon

Overview

abstract

  • Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural and numerical chromosomal abnormalities during cell division, which contributes to tumour genetic heterogeneity. CIN has long been recognized as a hallmark of cancer, and evidence over the past decade has strongly linked CIN to tumour evolution, metastasis, immune evasion and treatment resistance. Until recently, the mechanisms by which CIN propels cancer progression have remained elusive. Beyond the generation of genomic copy number heterogeneity, recent work has unveiled additional tumour-promoting consequences of abnormal chromosome segregation. These mechanisms include complex chromosomal rearrangements, epigenetic reprogramming and the induction of cancer cell-intrinsic inflammation, emphasizing the multifaceted role of CIN in cancer.

publication date

  • July 29, 2024

Research

keywords

  • Chromosomal Instability
  • Disease Progression
  • Neoplasms

Identity

Scopus Document Identifier

  • 85200002910

Digital Object Identifier (DOI)

  • 10.1038/s41576-024-00761-7

PubMed ID

  • 39075192

Additional Document Info

volume

  • 26

issue

  • 1