Comprehensive Geriatric Assessment to Optimize the Management of Older Patients With Transthyretin Cardiac Amyloidosis. Review uri icon

Overview

abstract

  • Transthyretin cardiac amyloidosis (ATTR-CA) predominantly affects older adults with multiple chronic conditions, leading to significant physical, cognitive, and emotional challenges. New disease-modifying drugs are effective in early stages, prompting a shift toward comprehensive assessments, including functional capacity and quality of life. However, these assessments may not fully capture the complexity of older ATTR-CA patients, especially regarding frailty and mood disorders, which can influence symptom reporting. Thus, integrating comprehensive geriatric assessment tools into routine clinical practice may be crucial to detect early signs of frailty or functional impairment that could impact outcomes and mitigate futility and ageism in the decision-making process. This review highlights the importance of evaluating multimorbidity, disability, and frailty in older patients with ATTR-CA to optimize management strategies.

publication date

  • July 22, 2024

Identity

PubMed Central ID

  • PMC11318635

Scopus Document Identifier

  • 85199219541

Digital Object Identifier (DOI)

  • 10.1016/j.jacadv.2024.101123

PubMed ID

  • 39140080

Additional Document Info

volume

  • 3

issue

  • 9