Real-Time Analysis of Conduction Disturbances During TAVR With the CARA Monitor.
Academic Article
Overview
abstract
BACKGROUND: The occurrence of conduction disturbances (CDs) remains the most frequent complication of transcatheter aortic valve replacement (TAVR). However, little is known about the timing of electrocardiogram (ECG) changes and CDs during the TAVR procedure. OBJECTIVE: To describe ECG changes throughout the TAVR procedure using the CARA monitor. METHODS: Multicenter study including 196 prospectively enrolled patients with no CDs undergoing TAVR. All patients were monitored with the CARA system, which uses a 12-lead ECG to measure PQ and QRS intervals, QRS axis, and variations with each heartbeat at every step: baseline, wire insertion, pre-dilatation, valve deployment, post-dilatation, and end of procedure. RESULTS: PQ and QRS intervals progressively increased throughout the procedure, with a cumulative increase from 169.0±20.0ms to 186.0±31.6ms (P<0.001) for the PQ interval and from 101.3±10.5ms to 126.0±25.4ms (P<0.001) for the QRS interval, from baseline to the end of the procedure. A significant increase in the number of patients with left axis deviation was observed (8% at baseline vs 32% at end of procedure, P<0.001). A total of 161 (82.4%) patients exhibited at least one CD episode (PQ>200ms, QRS>120ms, advanced heart block) during the procedure, with most episodes occurring during pre-dilatation and valve implantation maneuvers. CONCLUSIONS: The CARA system facilitated real-time ECG monitoring, detecting subtle and progressive changes during TAVR. ECG changes occurred at each step, with most patients experiencing CDs, especially during pre-dilatation and valve implantation. The potential of ECG dynamics and timing for early detection of severe CDs should be explored in future studies.
