Proinflammatory dietary pattern and risk of total and subtypes of breast cancer among US women.
Academic Article
Overview
abstract
BACKGROUND: Dietary patterns promoting chronic inflammation, including the empirical dietary inflammatory pattern (EDIP), have been associated with certain cancers. Investigating whether this dietary pattern is associated with breast cancer-where the role of inflammation is less well-defined-could provide valuable insights and potentially improve strategies for preventing this cancer. METHODS: We prospectively followed 76 386 women from Nurses' Health Study (NHS, 1984-2018) and 92 886 women from Nurses' Health Study II (NHSII, 1991-2019). Diet was assessed by food frequency questionnaires every 4 years, starting at baseline. The inflammatory potential of diet was evaluated using the validated EDIP based on plasma C-reactive protein, interleukin-6, and tumor necrosis factor α-R2. Higher scores indicate higher dietary inflammatory potential. Hazard ratios (HRs) and 95% confidence intervals (CIs) of overall and subtypes of breast cancer were estimated using multivariable-adjusted Cox regression models. RESULTS: During 4 490 842 person-years of follow-up, we documented 11 026 breast cancer cases. Women in the highest compared with the lowest EDIP quintile were at higher breast cancer risk (HRQ5vsQ1 = 1.12, 95% CI = 1.05 to 1.19; Ptrend < .001). The association was stronger for estrogen receptor negative tumors (HRQ5vsQ1 = 1.29, 95% CI = 1.09 to 1.53; Ptrend = .003). Also, we observed that the association of EDIP with breast cancer risk differed by molecular subtype, with the strongest association observed with basal-like tumors (HRQ5vsQ1 = 1.80, 95% CI = 1.20 to 2.71; Ptrend = .004). CONCLUSIONS: Higher EDIP scores were associated with a modestly increased risk of breast cancer, which was more pronounced for estrogen receptor negative and basal-like breast tumors. These results support the hypothesis that diet-related inflammation plays a role in breast cancer etiology, particularly tumors lacking hormone receptors.
