Dynamics of Immune Reconstitution and Impact on Outcomes across CAR-T Cell Products in Large B-cell Lymphoma. Academic Article uri icon

Overview

abstract

  • This study reveals differences in IR patterns after CAR-T therapy in patients with large B-cell lymphoma, with early NK cell recovery emerging as a key predictor of survival. These findings provide potential future avenues of research for improving patient outcomes and tailoring post-therapy management strategies to mitigate relapse risk.

authors

  • Luan, Danny
  • DeWolf, Susan
  • Fei, Teng
  • Raj, Sandeep
  • Shah, Gunjan L
  • Lareau, Caleb A
  • Alhomoud, Mohammad
  • Salles, Gilles
  • Rivas-Delgado, Alfredo
  • Rejeski, Kai
  • Park, Jae H
  • Luttwak, Efrat
  • Luna de Abia, Alejandro
  • Corona, Magdalena
  • Ntrivalas, Evangelos
  • Cassanello, Giulio
  • Gomez-Llobell, Marina
  • Parascondola, Allison
  • Scordo, Michael
  • Hsu, Katharine
  • Palomba, M Lia
  • Perales, Miguel-Angel
  • Shouval, Roni

publication date

  • March 4, 2025

Research

keywords

  • Immune Reconstitution
  • Immunotherapy, Adoptive
  • Lymphoma, Large B-Cell, Diffuse
  • Receptors, Chimeric Antigen

Identity

PubMed Central ID

  • PMC11876948

Scopus Document Identifier

  • 86000672645

Digital Object Identifier (DOI)

  • 10.1158/2643-3230.BCD-24-0163

PubMed ID

  • 39666878

Additional Document Info

volume

  • 6

issue

  • 2