Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery.
Review
Overview
abstract
The authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood brain and blood tumor barrier in a safe and effective manner.
