Scaling up neuronal Ca2+, signaling on ER ladders.
Academic Article
Overview
abstract
Dendritic Ca2+ signaling is critical for neural transmission and signal processing, however the detailed molecular mechanisms have not been elucidated. Using elegant and complementary imaging approaches Benedetti et al. discover a distinctive ER ladder architecture in dendrites and show that precise localization of Ca2+ signaling proteins at endoplasmic reticulum (ER)-plasma membrane (PM) junctions supports integration of Ca2+ signaling along the dendrite.
