Pharmacokinetic interaction of disulfiram and antidepressants. Academic Article uri icon

Overview

abstract

  • Intravenous imipramine and desipramine were administered to two detoxified alcoholics before and during disulfiram treatment. Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak plasma levels during disulfiram treatment.

publication date

  • November 1, 1985

Research

keywords

  • Desipramine
  • Disulfiram
  • Imipramine

Identity

Scopus Document Identifier

  • 0022410779

PubMed ID

  • 4061700

Additional Document Info

volume

  • 142

issue

  • 11