The treatment of tendinopathies can be challenging due to the wide heterogeneity in their clinical presentation, variable disease chronicity, and the lack of standardized treatment approaches. Orthobiologics such as platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and patch augmentation have been utilized with increasing frequency for the treatment of tendon injuries, but the evidence to support their routine use is mixed. This review summarizes the current clinical literature evaluating the efficacy of PRP, BMAC, and patch augmentation in the treatment of common tendon disorders.