A novel mechanism of immunoevasion by ER+ breast cancer. Academic Article uri icon

Overview

abstract

  • Estrogen receptor (ER)+ breast malignancies are poorly infiltrated by immune cells, hence exhibiting limited sensitivity to immune checkpoint inhibitors (ICIs). Recent data from Palomeque et al. demonstrate that ER signaling actively contributes to such an immunoevasive phenotype by preventing the nuclear factor LCOR from establishing an ICI-sensitive tumor microenvironment.

publication date

  • December 17, 2025

Research

keywords

  • Breast Neoplasms
  • Receptors, Estrogen
  • Tumor Escape

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.it.2025.12.003

PubMed ID

  • 41412836