Ischemic vs. Nonischemic Cardiomyopathy in TAVR for Moderate Aortic Stenosis: A TAVR UNLOAD Sub Analysis.

Overview

•This exploratory analysis of the Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure trial did not identify evidence of a differential treatment effect of transcatheter aortic valve replacement compared to clinical aortic stenosis surveillance according to cardiomyopathy etiology (ischemic versus nonischemic) in patients with heart failure with reduced ejection fraction and moderate aortic stenosis.•The study was underpowered to definitively exclude a potential modifying effect of cardiomyopathy etiology, and any differential treatment response may require longer follow-up to become apparent.