Allograft Rejection and the Latent HIV Reservoir in Kidney Transplant Recipients with HIV. Academic Article uri icon

Overview

abstract

  • People with HIV have higher risk for rejection after kidney transplantation but the mechanism is poorly understood. As HIV latency promotes immune dysregulation and chronic inflammation, we evaluated whether the size of the HIV latent viral reservoir (LVR) at baseline and through 52-weeks is associated with rejection in kidney transplant recipients with HIV from donors with and without HIV. Using the intact proviral DNA assay, we found no differences in the LVR between those who experienced rejection (n=14) versus those who did not (N=55) regardless of donor HIV status. These data support the feasibility of HIV+ to HIV+ organ transplantation. Clinical Trials Registration. NCT03500315.

authors

publication date

  • March 13, 2026

Identity

Digital Object Identifier (DOI)

  • 10.1093/infdis/jiag154

PubMed ID

  • 41823991