Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903-induced Skin Inflammation. Academic Article uri icon

Overview

abstract

  • Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 needed for TSLP signaling has been unclear. We found that LCs express both receptor chains needed by TSLP (CD127 and TSLPR) and upregulate the TSLPR upon Calcipotriol (MC903)-induced inflammation.

publication date

  • April 1, 2026

Research

keywords

  • Cytokines
  • Interleukin-7 Receptor alpha Subunit
  • Langerhans Cells
  • Receptors, Cytokine
  • Skin

Identity

PubMed Central ID

  • PMC13036299

Digital Object Identifier (DOI)

  • 10.1002/eji.70178

PubMed ID

  • 41913338

Additional Document Info

volume

  • 56

issue

  • 4