Discordance between patient and physician global assessments in early systemic sclerosis.
Academic Article
Overview
abstract
OBJECTIVE: This study aims to identify factors associated with patient and physician global assessments and discordance between them in systemic sclerosis (SSc). METHODS: Data from adults with early SSc (< 5 years) from the CONQUER registry were included. Patient (PtGA) and physician (PhGA) global assessments (0-10 scale), clinical evaluations, and patient-reported outcomes (PROs) were collected every 6 months. Multivariable mixed-effects linear regression identified factors associated with PtGA and PhGA using i) clinical variables, and ii) clinical variables plus PROs. Relative weight analysis (RWA) determined the relative importance of each variable. Discordance (≥ 2-points between PtGA and PhGA) was assessed using multinomial mixed-effects logistic regression. RESULTS: Among 956 patients (83% female, 33% limited disease), mean (SD) PtGA and PhGA at enrollment were 4.2 (2.6) and 3.4 (2.0), respectively (p<0.001). RWA of clinical variables identified modified Rodnan Skin Score (mRSS) and New York Heart Association (NYHA) functional class as most influential for both global assessments. After including PROs, PtGA was most influenced by measures of pain, skin symptoms, and physical function. Discordance occurred in 53% of patients (35% PtGA worse; 18% PhGA worse). Worse PtGA was associated with higher overall pain/discomfort. Worse PhGA was associated with higher mRSS, worse NYHA class, higher pain interference, and lower diffusing capacity of the lung. CONCLUSION: Discordance between PtGA and PhGA occurs commonly, highlighting the need for comprehensive symptom management and measurement of disease burden in this complex disease. In SSc, differences in global assessments by patients and physicians reflect dissimilar weighting of data elements.
