Respiratory-Swallow Training and Variable Practice in Parkinson's Disease: A Clinical Trial Pilot Study.
Academic Article
Overview
abstract
PURPOSE: Dysphagia in people with Parkinson's disease (PwPD) is closely linked to impairments in respiratory-swallow coordination. Respiratory-swallow training (RST) is a promising, mechanism-based intervention for dysphagia, but to date, only a single-subject study has examined RST in PwPD. As an early-stage next step in refining RST for PwPD, this clinical trial pilot study aimed to: (1) explore the preliminary associations between exhale-swallow-exhale RST and swallowing safety, swallowing efficiency, and respiratory phase patterning; and (2) explore differences in practice structure (constant vs. variable practice) on RST-related motor learning outcomes. METHOD: PwPD completed pre-RST assessments, four once-weekly sessions of RST targeting only the exhale-swallow-exhale pattern, and post-RST assessments. Participants were randomized to constant practice or variable practice training conditions. Outcomes were measured using nasal airflow, respiratory inductive plethysmography, submental surface electromyography, and FEES. Multilevel statistical models were used to evaluate changes in exhale-swallow-exhale usage, pharyngeal residue, penetration, and aspiration. RESULTS: 12 PwPD completed all study phases, yielding an analysis of 1,565 swallows. In this pilot sample, exhale-swallow-exhale usage was higher post-RST compared to pre-RST (p < .05), with exhale-swallow-exhale usage observed to be higher at 1-month follow-up in the variable practice group compared to the constant practice group (p < .05). Additionally, pharyngeal residue, laryngeal vestibule residue, vocal fold residue, and Penetration-Aspiration Scale scores were lower post-RST compared to pre-RST (p < .05), (p < .05). CONCLUSIONS: This clinical trial pilot study provides preliminary evidence that RST may be associated with increased exhale-swallow-exhale usage, swallowing safety, and swallowing efficiency in PwPD. Preliminary evidence also suggests that variable practice may enhance retention and generalization of exhale-swallow-exhale usage, warranting further evaluation. Findings from this study will be used to inform refinement of RST for PwPD and the design of future confirmatory randomized clinical trials.
