Induction of IgE antibodies to antigen isolated from tobacco leaves and from cigarette smoke condensate. Academic Article uri icon

Overview

abstract

  • Neonatal California White rabbits were sensitized with a glycoprotein purified from cured Virginia Bright tobacco leaves. Their serums, but not serums from normal rabbits, were demonstrated by passive cutaneous anaphylaxis technique to contain heat-labile, homocytophilic antibodies to this antigen and to similar material purified from cigarette smoke condensate. Serums containing IgE antibodies to tobacco antigen would not be demonstrated to contain hemagglutinating antibodies to this antigen. These experiments demonstrate that antigen capable of triggering specific IgE-mediated release of inflammatory mediators is present in cigarette smoke. It can be hypothesized that IgE-mediated responses to antigen in cigarette smoke are causally related to the development of vascular injury and of myocardial arrhythmia in hypersensitive smokers.

publication date

  • July 1, 1979

Research

keywords

  • Antigens
  • Glycoproteins
  • Immunoglobulin E
  • Nicotiana
  • Plant Proteins
  • Plants, Toxic
  • Smoke
  • Tobacco

Identity

PubMed Central ID

  • PMC2042358

Scopus Document Identifier

  • 0018353398

PubMed ID

  • 464022

Additional Document Info

volume

  • 96

issue

  • 1