Light and electron microscopic localization of enkephalin and tyrosine hydroxylase in neostriatum of fetal and adult rat brain.
Academic Article
Overview
abstract
In fetal rat brain, immunocytochemical localization of tyrosine hydroxylase and methionine (Met5)-enkephalin demonstrates that dopaminergic axons labeled with the biosynthetic enzyme can be detected in th neostriatum prior to the appearance of the peptide in neuronal perikarya. The tyrosine hydroxylase-labeled axon terminals in adult neotriatum may form axodendritio synapses with neurons containing enkephalin. However the majority of the dopaminergic axon terminals lack synaptic specializations in the mature neostriatum.
