Inhibition of Candida albicans--induced lymphocyte proliferation by lymphocytes and sera from women with recurrent vaginitis. Academic Article uri icon

Overview

abstract

  • To investigate whether there was an immunologic basis for recurrent Candida albicans-induced vaginitis, peripheral blood lymphocytes were isolated from six women with this disorder and from six healthy control women. No differences were observed in the proliferative responses of peripheral blood lymphocytes to mitogens. However, only the control peripheral blood lymphocytes proliferated in response to a C. albicans extract. Furthermore, patients' lymphocytes or serum suppressed the proliferative response of control lymphocytes to C. albicans but not to mitogens. Women with recurrent C. albicans vaginitis appear to produce Candida-specific suppressor lymphocytes which block the cellular immune response to this organism.

publication date

  • December 1, 1983

Research

keywords

  • Candida albicans
  • Candidiasis
  • Lymphocyte Activation
  • T-Lymphocytes, Regulatory
  • Vaginitis

Identity

Scopus Document Identifier

  • 0021058357

PubMed ID

  • 6228146

Additional Document Info

volume

  • 147

issue

  • 7