Stimulation of lymphokine production by teleocidin, aplysiatoxin, and debromoaplysiatoxin. Academic Article uri icon

Overview

abstract

  • Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2). This study shows that three compounds structurally unrelated to TPA, previously shown to mimic TPA in some other biological activities, are similar to TPA in stimulating IFN-gamma and Il-2 production in cultures of human peripheral blood lymphocytes. The production of another lymphokine, termed lymphotoxin (LT), was also enhanced by TPA and the other three compounds examined. Maximal enhancement of lymphokine production was observed in cultures costimulated with TPA or one of the other tested compounds and phytohemagglutinin (PHA). TPA was separated from IFN-gamma during a multistep purification procedure.

publication date

  • July 15, 1983

Research

keywords

  • Interferon Inducers
  • Interferon-gamma
  • Interleukin-2
  • Lymphotoxin-alpha
  • Lyngbya Toxins
  • Marine Toxins

Identity

Scopus Document Identifier

  • 0020508498

PubMed ID

  • 6409425

Additional Document Info

volume

  • 79

issue

  • 2