Experimental and clinical activity of mitomycin C and cis-diamminedichloroplatinum in malignant mesothelioma. Academic Article uri icon

Overview

abstract

  • Little information is available regarding the effectiveness of chemotherapeutic agents in malignant mesothelioma. Human malignant mesothelioma specimens from two patients were successfully transplanted and maintained in homozygous nude mice. Screening of chemotherapeutic agents revealed that cisplatin was the most active single agent in one line, and mitomycin C in the other. The combination of mitomycin C and cisplatin, however, was the most effective regimen for both lines of xenografted human mesothelioma. Based on these results in nude mice, a clinical trial of mitomycin C and cisplatin was undertaken. Four of 12 patients showed objective response (one complete and three partial). These clinical results support the usefulness of the nude mouse model for malignant mesothelioma.

publication date

  • April 1, 1984

Research

keywords

  • Antibiotics, Antineoplastic
  • Antineoplastic Combined Chemotherapy Protocols
  • Cisplatin
  • Mesothelioma
  • Mitomycins

Identity

Scopus Document Identifier

  • 0021248187

PubMed ID

  • 6423278

Additional Document Info

volume

  • 44

issue

  • 4