Antigrowth effect of polyamine biosynthesis inhibitors on the Dunning R 3327-G prostatic tumor. Academic Article uri icon

Overview

abstract

  • alpha-Difluoromethylornithine (DFMO) and methylglyoxal-bis-guanylhydrazone (MGBG), when administered simultaneously, inhibited growth and were highly toxic to the Dunning R 3327-G hormone-resistant prostatic adenocarcinoma transplanted into Copenhagen rats. Neither DFMO (2%) nor MGBG at a nontoxic dose (15 mg/kg) inhibited tumor growth, but total (47% early cure rate) or near total suppression of growth of established tumors was observed in rats receiving both treatments.

publication date

  • January 1, 1984

Research

keywords

  • Adenocarcinoma
  • Guanidines
  • Mitoguazone
  • Ornithine
  • Polyamines
  • Prostatic Neoplasms

Identity

Scopus Document Identifier

  • 0021138734

PubMed ID

  • 6429652

Additional Document Info

volume

  • 5

issue

  • 4