Plasma exchange treatment of peripheral neuropathy associated with plasma cell dyscrasia. Academic Article uri icon

Overview

abstract

  • Plasma exchange was used to treat 10 patients with polyneuropathy and a monoclonal antibody (plasma cell dyscrasia). Six patients had improvement of the neuropathy, while three patients had stabilisation of the neuropathy during plasma exchange. The patients who improved maintained a 64% or greater decrease in the monoclonal antibody between exchanges. Patients with axonal polyneuropathy as well as patients with demyelinating polyneuropathy recovered some neurologic function. With cessation of plasma exchanges, the monoclonal antibody titre approached pre-treatment levels and the neuropathy progressed. Plasma exchange was effective in rapidly lowering the level of monoclonal antibody and allowing for some recovery of neurologic function.

publication date

  • August 1, 1984

Research

keywords

  • Paraproteinemias
  • Plasma Exchange
  • Polyneuropathies

Identity

PubMed Central ID

  • PMC1027944

Scopus Document Identifier

  • 0021210917

PubMed ID

  • 6470723

Additional Document Info

volume

  • 47

issue

  • 8