The previously unreported association of chronic persistent cough due to a duplication esophageal cyst is presented. The presence of a long history of atopy, bronchitis, and asthma resulted in a delay in diagnosis. When vigorous bronchodilator therapy was unsuccessful, close observation of the patient and review of her radiographs suggested the esophageal etiology of her cough. This case reinforces the observation that chronic persistent cough, although common, may present a very perplexing problem. A systematic approach considering the anatomy of the cough reflex, and an awareness of the esophageal and other nonpulmonary causes of cough, can aid in diagnosis and management of these patients.
