Prognostic significance of changes in serum transcobalamin levels in cancer patients with chemotherapy-induced granulocytopenia. Academic Article uri icon

Overview

abstract

  • Serum transcobalamin (TC) levels were determined daily in 14 adults suffering from advanced nonhematological malignancies and hospitalized because of chemotherapy-induced leukopenia and fever. Even during the nadir leukocyte count, TCI and TCIII serum levels were normal or only slightly decreased indicating that bone marrow activity was not completely suppressed. A significant increase in serum TCII level was observed in all patients, with peak values occurring an average of 4.5 days from admission at a time when the median leukocyte count was 2,300/mm 3. Full white cell count recovery followed this peak TCII elevation within a mean of 5.5 days in all patients, coinciding with a fall in TCII levels to basal values. The rise in serum TCII level appears to be an early indicator for imminent bone marrow recovery in myelosuppressed patients.

publication date

  • January 1, 1983

Research

keywords

  • Agranulocytosis
  • Antineoplastic Agents
  • Blood Proteins
  • Neoplasms
  • Transcobalamins

Identity

Scopus Document Identifier

  • 0020522971

PubMed ID

  • 6843947

Additional Document Info

volume

  • 40

issue

  • 3