Phase I evaluation of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) by a weekly iv dose schedule. Academic Article uri icon

Overview

abstract

  • 4'-(9-Acridinylamino)methanesulfon-m-anisidide (AMSA), a derivative of acridine, was evaluated in patients with advanced malignant neoplasms in a phase I clinical trial. The drug was administered in an iv infusion on a weekly x 4 schedule. Seventy-four courses of AMSA were administered to 34 patients over a dose range of 20-90 mg/m2. Dose-limiting toxicity, which was solely hematologic, was observed at 90 mg/m2. Objective antitumor effects were observed in two of 22 evaluable patients: a partial remission in a patient with abdominal desmoid fibrosarcomas and a minor regression in a patient with adenocarcinoma of the colon. A dose of 70-90 mg/m2 would be suitable for trials of AMSA on a weekly basis.

publication date

  • January 1, 1980

Research

keywords

  • Aminoacridines
  • Antineoplastic Agents

Identity

Scopus Document Identifier

  • 0018836771

PubMed ID

  • 6892893

Additional Document Info

volume

  • 64

issue

  • 1