Acquired Pelger-Huët nuclear anomaly with tuberculosis. Academic Article uri icon

Overview

abstract

  • Karel Pelger described an abnormality of granulocyte nuclear segmentation in the context of advanced tuberculosis, but G. Huët questioned this association. It is now recognized that the Pelger-Huët nuclear anomaly (PHNA) can be either hereditary or acquired with systemic diseases, commonly hematologic dysplasias. An association with tuberculosis has never been well verified. The man described in our study had cachexia, high fevers, severe hypoproliferative anemia, and acquired PHNA. At autopsy, an overwhelming tuberculosis was discovered in the absence of any other underlying disease. Acquired PHNA may serve as a diagnostic and prognostic indicator in tuberculosis.

publication date

  • January 1, 1982

Research

keywords

  • Pelger-Huet Anomaly
  • Tuberculosis

Identity

Scopus Document Identifier

  • 0020003133

PubMed ID

  • 7053717

Additional Document Info

volume

  • 142

issue

  • 1